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The receptor then desensitizes swiftly and enters within a transient inactive condition, characterised from the presence of sure agonist (By similarity). While in the presence of CACNG4 or CACNG7 or CACNG8, demonstrates resensitization which is characterized by a delayed accumulation of recent flux on continued application of L-glutamate (By similarity). By intricate formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR as well as endosomal sorting in the GRIA2 subunit toward recycling and membrane focusing on (By similarity)

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Following binding acetylcholine, the AChR responds by an in depth adjust in conformation that impacts all subunits and causes opening of an ion-conducting channel across the plasma membrane permeable to sodium ions

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